Funnily enough, I'm not really working on much, if any anime fanart. Closest thing to anime I'm doing would be Avatar: The Last Airbender, and that's not even really an Anime. Mostly doing stuff from video games, since that's more where my interest lies, and is usually what I go to conventions for. Fanime might be for anime, but the gaming community there is alive and strong. So, Portal 2 references, here I come. lol.
And yeah, I agree that doing Pony stuff would be a good way to go, considering how fast that fandom grew recently. Not really my thing, but definitely a good idea for others to do, and I'm guessing we'll be seeing a lot of it this year.