You know that hot guy at work who always smiles at you? He's gay.
Your outfit isn't really cute. I was just being a bitch.
You weren't his/her first.
You remember when you were so pretty and popular in high school? Too bad no one cares.
A college degree works against you in a Recession.
There's still no cure for AIDS.
Insurance companies will find any way they can NOT to pay your claim, no matter how legitimate.
Politicians couldn't care less about you.
Sometimes friendship is a cover for jealousy.
and finally,
You can't take it with you when you die.