500 (?) anime titles that fans need to watch

[Necara]

328. Pretear

[summerchristmas838]

327) baccano
just because.

[hikarihoshi28]

326. Heat Guy J
325. Whisper of the Heart  (Ghibli film)

[BunofGovt]

324. GetBackers
323. Cromartie High School
322. They Were Eleven
321. Ranma 1/2 (I dont' remember seeing this on the list from Dentyneice408, sorry if it's already there)
320. Tsukikage Ran

[Barnes]

319. DNA^2 (TV series and oavs)

[BunofGovt]

318. Mushishi
317. Kino's Journey

[hikarihoshi28]

316. Lupin III: Castle of Cagliostro  (Miyazaki's first film as director)

[DentyneIce408]

Update!

500. Fist of the North Star (1980s tv series)
499. Neon Genesis Evangellion
498. Cowboy Bebop
497. Trigun
496. FLCL
495. Mobile Fighter G Gundam
494. Rurouni Kenshin
493. Martiam Successor Nadesico
492. Gundam Wing
491. Golgo 13 (tv series)
H.M: Golgo 13: The Professional (1983 movie)
490. Samurai Champloo
489. Tengen Toppa Gurren Lagann
488. Samurai 7
487. Azumanga Diaoh
486. Hellsing Ultimate
485. Fullmetal Alchemist
484. Outlaw Star
483. Leda: The Fantastic Adventure of Yohko
482. Assemble  Insert
481. .hack//Sign
480. Otaku no Video
479. Dragon Ball
478. Nadia, Secret of the Blue Water
477. Macros Plus
476. Yu Yu Hakusho
475. Paradise Kiss
474. Wolf's Rain
473. Castle in the Sky
472. Gundam 0080 War in the Pocket
471. Eden of the East
470. Dead Leaves
469. Eureka Seven
468. Ninja Scroll (movie)
467. Gunbuster
466. Read or Die OVA
465. Diebuster
464. AKIRA
463. Grenadier
462. Princess Mononoke
461. Death Note
460. Bubblegum Crisis Oav
H.M: Bubblegum Crash
459. Perfect Blue
458. GaoGaiGar
H.M: GaoGaiGar Final
457. Otomo Katsuhiro's "Memories"
456. Haunted Junction
455. Sailor Moon
454. Ashita no Joe
453. Welcome to the N.H.K.
452. Air Gear
451. Lucky Star
450. Fullmetal Alchemist Brotherhood
449. Vampire Hunter D
448. Area 88 oavs
447. Gun X Sword
446. Princess Nine
445. Ghost in The Shell (TV series)
H.M: Ghost in The Shell 1st Evolution
444. Now and Then, Here and There
443. Great Teacher Onizuka
442. Abenobashi Mahō Shōtenga
441. Gunsmith Cats
440. Honoo no Haramase Tenkousei (hentai)
439. KITE (Director's Cut)
438. Project A-Ko
437. Captain Harlock - Main Series
H.M: Arcadia of My Youth
436. Gundam Seed
435. Jojo's Bizarre Adventure (1993 oavs)
H.M: Jojo's Bizarre Adventure (2000 prequel oavs)
434. Stellvia of the Universe
433. Getter Robo
432. Robotech
431. Slayers 
H.M: Slayers NEXT, TRY, AGAIN, and REVOLUTION
430. School Rumble
429. Ai Yori Aoshi
428. Burst Angel
427. Kino no Tabi
426. Love Hina
425. Tetsujin 28 Go
424. Astro Boy
423. Haibane Renmei
422. Please Teacher!
421. Speed Racer
420. Basilisk
419. Elfen Lied
418. Code Geass
417. Strain
416. Keroro Gunso
415. Ghost Hunt
414. D. Gray-man
413. The Melancholy of Haruhi Suzumiya
412. Highschool of the Dead
411. Ouran High School Host Club
410. Welcome to the NHK
409. Fushigi Yuugi
408. Venus Wars
407. Afro Samurai
406. VanDread
405. Angelic Layer
404. Interstella 5555 (5tory of the 5ecret 5tar 5ystem)
403. Magic Knight Rayearth
402. Chobits
401. Cosplay Complex
400. He Is My Master
399. Air 
398. Kanon (2006)
397. Dirty Pair (original)
H.M: Dirty Pair Flash
396. Clannad
395. 5 Centimeters per Second
394. Fruits Basket
393. Pet Shop of Horrors
392. Scrapped Princess
391. Chrono Crusade
390. GoLion
389. I My Me! Strawberry Eggs!
388. They are My Noble Masters
387. Future Boy Conan
386. 8-Man
385. Yoroiden Samurai Troopers (Ronin Warriors)
384. Orochuban Ebichu
383. Saint Seiya (Knights of the Zodiac)
382. Dominion Tank Police 
H.M: New Dominion Tank Police, and TANK S.W.A.T. 01
381. Negima!? (Anime)
H.M: Negima! Magister Negi Magi (Anime)
379. Yatterman
378. Witch Hunter Robin 
377. Detective Conan
376. Hanbun no Tsuki ga Noboru Sora
375. K-On!
H.M: K-On!!
374. NANA
373. Seto no Hanayome
372. Bleach
371. Needless
370. Legend of the Galactic Heroes
369. Hetalia
368. Cardcaptor Sakura
367. Tsubasa Chronicles
366. Fancy Lala
365. Urotsukidoji: Legend of the Overfiend
364. Berserk
363. Legendz: Yomigaeru Ryuuou Densetsu
362: KissXSis
361. Mezzo Forte
360. Star Blazers (Space Battleship Yamato)
359. The Irresponsible Captain Tylor
358. Shakugan no Shana
357. Snow Drop 
356. Panty & Stocking with Garterbelt
355. Rozen Maiden
H.M: Rozen Maiden: Traumend and Ouverture 
354. Angel's Egg
353. Sora no Iro, Mizu no Iro (Hentai) 
352. Casshern
351. Yosuga no Sora  
350. Akazukin Cha-Cha
349. Lupin III 
348. Kore wa Zombie Desu ka? 
347. Initial D
H.M: Extra Stage; Special Stage 1-2; Stages 1-4
346. Wangan Midnight 
345. My Neighbor Totoro
344. Grave of the Fireflies
343. Aquarion
342. Blassreiter 
341. Claymore 
340. Morbito
339. Nyan Koi!
338. Kodomo no Jikan
337. Ghost Hound
336. Saber Marionette 
H.M: Saber Marionette J; J to X; J Again; R
335. Yamato Nadeshiko Shichi Henge (THe Wallflower)
334. Kaze no Stigma
333. Rio - Rainbow Gate
332. Gintama 
331. Girls High
330. Mononoke (the series with the medicine seller, not Princess Mononoke)
329. Master Keaton
328. Pretear
327. Baccano
326. Heat Guy J
325. Whisper of the Heart  (Ghibli film)
324. GetBackers
323. Cromartie High School
322. They Were Eleven
321. Ranma 1/2
320. Tsukikage Ran
319. DNA^2 (TV series)
H.M: DNA^2 Ova
318. Mushishi
317. Kino's Journey
316. Lupin III: Castle of Cagliostro  (Miyazaki's first film as director)
-----
315. Linebarrels of Iron
H.M: Linebarrels of Iron Ova
314: Last Exile
313: Chrome Shelled Regios
312: Shiki
311: Tokyo Majin 

[Barnes]

Keep up the good work, folks.

310. Mazinkaiser SKL

[hikarihoshi28]

309. Gurren Lagann

[Barnes]

309. Gurren Lagann

That's already been mentioned at 489. Sorry.

[DentyneIce408]

309. Queen's Blade: The Wandering Warrior
H.M: Queen's Blade: The Queen's Throne
308. Bible Black (Hentai)
307. Daiakuji (Hentai)
306. Fruits Cup (Hentai)
305. Little Monica (Hentai)

[DentyneIce408]

304. Ga-Rei-Zero
303. Madlax
302. MAR (one of my fav. anime/manga)
301. Naoki Urasawa's Monster
300. Sengoku Basara: Samurai Kings

[questionette]

299. Death Note

...I was suprised no one has mentioned it yet :O especially if this list isn't in any particular order!

298. Soul Eater
297. Spirited Away

[Barnes]

Death Note is at number 461.

297. Demon Fighter Kocho

[Kuudere]

296. Puella Magi Madoka Magica

Just had to get that one in there. :D

[G.I.R]

295 Oh! Edo Rocket

[questionette]

294.  Blue Exorcist

[psycoreaper]

293. Elfen Lied

[Barnes]

293. Elfen Lied

Sorry, that's been listed already.

293. Giant Robo
292. Genocyber