Some great tips in here already!
- Pick up your badge on Thursday. Last year they announced they would open at 3 PM, but they actually opened at Noon and by the time I got there (around 1 PM?) there was no line and I just breezed right through and got my badge. That being said, past performance is no guarantee of future results so do plan on being there early to get your badge.
-The schedule is your friend. As others have mentioned it's easy to lose track of time wandering around Artist Alley and the Dealers Hall, but there is always great stuff being shown in the video rooms, fun panels and of course guest panels too! When you pick up your badge there will most likely be a pocket schedule/guide in the bag. Review it! The first real "event" of Fanime is the swap meet on Thursday night, and being staff for that event I would highly encourage you to come! However, between picking up your badge and swap meet you can familiarize yourself with the goings-on of the weekend and plan accordingly.
- Food. It can easily chew away (haha) at your budget if you're not careful. Do you have a hotel room? If so, bring flats of water, buy sodas or whatever you want to drink in bulk and snacks to keep you sustained throughout the day. There are some great options for food near the con that aren't too expensive, so familiarize yourself with the area via google maps, or take advantage of that "downtime" on Thursday between picking up your badge and the swap meet. If you don't have a hotel room, a cooler in the back of your car can house your snacks/lunch throughout the day and you can come back to that as a rally point when you need to recharge.
- Now this depends on what kind of shopper you are but I generally stay away from the dealers hall for the first hour or two that it's open. The main reason being that there's usually a very large line and in my experience the "first in the door" don't really have an advantage over anyone else since the layout is different every year and there aren't too many "exclusive" items. Of course, if you want to be first in line you are welcome to do so, but be prepared to be sitting in that line for 3-5 hours in the early morning on Friday. I've found that it's better to just saunter in a bit later in the afternoon on Friday and peruse at a more leisurely pace.
- Save money for Monday. On the topic of the dealers hall, by late morning/early afternoon Monday, a lot of vendors will be having "closeout" deals. It's not guaranteed, but maybe you get a better price on some manga, or can negotiate a slightly lower price on some wall scrolls. Not only that, it's a total bummer when you're broke by Sunday afternoon and have to drag through the rest of the con with no money!
There's so much to see and do! The convention is pretty big, but once you've been wandering the first couple days you get into the swing of things by Saturday and have a good idea where everything is.
This year will be my 11th year and I still have a blast! Have a great con!